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Figure 6 | Molecular Neurodegeneration

Figure 6

From: Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury

Figure 6

Hdac3 cKO blocked heterochromatin formation in the GCL 5 days following ONC. (A-B) TEM images of cells in the GCL of a Rosa26-Tomatofl/fl control eye and AAV2-Cre/GFP injected eye, 5 days after ONC. Prominent heterochromatin formation is evident in the GCL of Rosa26-Tomatofl/fl crushed retinas. (C-D) TEM images of cells in the GCL of an Hdac3fl/fl control eye and Hdac3 cKO crushed eye indicate no heterochromatin formation in the GCL as a result of ONC. Nuclei with characteristics of the morphological scores described in Figure 4 are indicated. N = nucleus, n = nucleolus, ne = nuclear envelope, and m = Müller endfoot. (Scale bar: 3 μm).

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Molecular Neurodegeneration

ISSN: 1750-1326