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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Altered synaptic structure in the hippocampus in a mouse model of Alzheimer’s disease with soluble amyloid-β oligomers and no plaque pathology

Figure 4

PSD length is significantly decreased in mushroom spines in DU mice. The synapse density of perforated and non-perforated synapses in WT and DU mice remained unchanged (A & B), and the maximum head diameter of synapses and PSD lengths was also unchanged across genotypes in the SR and SLM dendritic region (C & D, n = 10/genotype). When synapses only on mushroom spines in the SR were analyzed, synapse head diameter remained constant, whereas a significant decrease in PSD length of DU synapses was observed (E & F, *p < 0.05, two-tailed t-test, n = 5/genotype). Data represent group mean ± SEM.

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Molecular Neurodegeneration

ISSN: 1750-1326