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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Altered synaptic structure in the hippocampus in a mouse model of Alzheimer’s disease with soluble amyloid-β oligomers and no plaque pathology

Figure 5

Identification of axospinous synapses using the disector method. Electron micrographs depicting synapses counted using the disector method (A & B). Only asymmetric axospinous synapses that are present in the reference panel (purple or blue), but not in the look-up panel were counted. Synapses present in both panels (green) were not included in the analysis. Perforated synapses (C, purple) were classified by the presence of a discontinuity (or more than one) within the postsynaptic density (PSD) as shown by the vector arrows. Maximum head diameter of synapses and PSD length were measured as indicated in D (scale bars = 500 nm).

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