Thiamet-G prevents cognitive decline in the TAPP mice. A, B. Beginning at 30-32 weeks of age 0, 200 or 500 mkd Thiamet-G treated TAPP mice were tested for cognitive performance in the Morris water maze (MWM). Learning curves were recorded during five consecutive days of training. No significant difference was observed between any of the groups in latency to solve the maze (A) and while a significant main effect was noted by the ANOVA for distance travelled, the post-hoc Tukey’s analysis revealed that there were no significant differences between groups. (B). C. During the probe trial, the latency to solve the maze was recorded and the control TAPP mice (0 mkd Thiamet-G) show significant cognitive impairment compared to untreated age-matched wild-type mice. Conversely, 500 mkd resulted in better performance than the 0 mkd Thiamet-G treated TAPP mice while the performance of 200 mkd TAPP mice is indistinguishable from the untreated age-matched wild-type mice. D. No differences were observed in the distance travelled during the probe trial. Error bars represent standard deviation (± S.D) and p-value result from a one-way analysis of variance (ANOVA) For all panels, n =8 for 0 mkd wild-type mice, n =17 for 0 mkd TAPP mice, n =17 for 500 mkd TAPP mice and n =19 for 200 mkd TAPP mice.