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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

Figure 3

Thiamet-G does not alter total tau or phospho-tau levels in the TAPP mice. A. Total tau (92e) blots indicate that levels of total tau are not altered by Thiamet-G treatment. Western blots using phosphorylation state sensitive tau antibodies, pS199/pS202, pT205, pT212, pT214, pT217, pT231, pS262/pS356, pS396, and pS396/pS404 indicate that levels of phospho-tau are also not significantly altered. Quantification by densitometry of each total or phospho-tau epitope is shown to the right. Phospho-tau immunoreactivity is normalized to total tau (92e) in each case. N =10 in each group. B. IHC analysis using phosphorylation state sensitive tau antibodies, pS199/pS202, pS396, pS396/pS404, pT231, pS262/pS356 indicate that levels of phospho-tau are also not significantly altered in the hippocampus, the amygdala, or the pons in either of the 200 or 500 mkd Thiamet-G treated TAPP mice groups. Error bars represent standard error of the mean (± S.E.M).

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Molecular Neurodegeneration

ISSN: 1750-1326