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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

Figure 5

40 and Aβ 42 levels. ELISA assays for Aβ40 and Aβ42 were used to assess the quantity of each of these species in the 0, 200 or 500 mkd Thiamet-G treated TAPP mice groups. A. 500 mkd was sufficient to reduce the amount of Aβ42 by half while 200 mkd was ineffective. B. 500 mkd Thiamet-G also showed a trend toward less Aβ40 which was not evident in the 200 mkd group. Error bars represent standard error of the mean (± S.E.M) and p-values result from student’s unpaired two-tailed t-tests For all panels, N =14 for 0 mkd TAPP mice, N =16 for 500 mkd TAPP mice and N =13 for 200 mkd TAPP mice.

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