Figure 5From: Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant miceAβ 40 and Aβ 42 levels. ELISA assays for Aβ40 and Aβ42 were used to assess the quantity of each of these species in the 0, 200 or 500 mkd Thiamet-G treated TAPP mice groups. A. 500 mkd was sufficient to reduce the amount of Aβ42 by half while 200 mkd was ineffective. B. 500 mkd Thiamet-G also showed a trend toward less Aβ40 which was not evident in the 200 mkd group. Error bars represent standard error of the mean (± S.E.M) and p-values result from student’s unpaired two-tailed t-tests For all panels, N =14 for 0 mkd TAPP mice, N =16 for 500 mkd TAPP mice and N =13 for 200 mkd TAPP mice.Back to article page