Figure 3
From: Pathogenic polyglutamine expansion length correlates with polarity of the flanking sequences
Calculation of Edge Polarity Index. The polarity profile is shown for the polyQ stretch and immediate flanking regions for Htt (A) and ATN1 (B). The polarity index of naked polyQ stretch (3.5) is shown by orange. The polarity index of flanking regions are shown by grey. Effective increase of polarity index on the edges of polyQ sequence is shown by red. Effective decrease of polarity index on the edges of polyQ sequence is shown by yellow. NPI and CPI indexes were calculated by integrating edge polarity effects at amino-terminal and carboxy-terminal ends of polyQ sequence.