From: Pathogenic polyglutamine expansion length correlates with polarity of the flanking sequences
Disease | Protein | Localization | Qth | NPI | CPI | EPI | Neuropathology |
---|---|---|---|---|---|---|---|
HD | Htt | Cytoplasm | 35 | 7.925 | -2.047 | 5.878 | Striatum, Cortex |
SBMA | AR | Nucleus, Cytoplasm | 38 | -3.658 | 19.475 | 15.817 | Spinal cord, Brain stem |
DRPLA | ATN1 | Nucleus, Cytoplasm | 49 | 53.530 | 36.706 | 90.236 | Cerebellum, Basal ganglia |
SCA1 | Atxn1 | Nucleus | 39 | 35.109 | 25.323 | 60.432 | Cerebellum, Brain stem |
SCA2 | Atxn2 | Cytoplasm | 32 | 13.614 | -2.222 | 11.392 | Cerebellum, Brain stem |
SCA3 | Atxn3 | Nucleus, Cytoplasm | 54 | 20.552 | 12.979 | 33.531 | Ventral pons, Substantia nigra |
SCA6 | CACN1A | Plasma Membrane | 20 | - | - | - | Cerebellum |
SCA7 | Atxn7 | Nucleus, Cytoplasm | 37 | 19.309 | -2.047 | 17.262 | Cerebellum, Brain stem, Spinal cord |
SCA17 | TBP | Nucleus | 47 | 26.816 | -3.758 | 23.058 | Cerebellum, Striatum |