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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Tau deletion impairs intracellular β-amyloid-42 clearance and leads to more extracellular plaque deposition in gene transfer models

Figure 5

Increased Aβ1-42 plaque deposition in Tau−/−mice. Staining of 20 μm thick coronal sections with 6E10 and DAB in wild type mice injected with lentiviral A) Aβ1-42 + DMSO, B) Aβ1-42 + Nilo, C) Aβ1-42 + Tau + DMSO, D) Aβ1-42 + Tau + Nilo and E) LacZ + DMSO in the hippocampus. Staining of 20 μm thick coronal sections with 6E10 and DAB in Tau−/− mice injected with lentiviral F) Aβ1-42 + DMSO, G) Aβ1-42 + Nilo, H) Aβ1-42 + Tau + DMSO, I) Aβ1-42 + Tau + Nilo and J) LacZ + DMSO in the cortex. Staining of 20 μm thick coronal sections with 6E10 and DAB in wild type mice injected with lentiviral K) Aβ1-42 + DMSO, L) Aβ1-42 + Nilo, M) Aβ1-42 + Tau + DMSO, N) Aβ1-42 + Tau + Nilo and O) LacZ + DMSO in the cortex. Staining of 20 μm thick coronal sections with 6E10 and DAB in Tau−/− mice injected with lentiviral P) Aβ1-42 + DMSO, Q) Aβ1-42 + Nilo, R) Aβ1-42 + Tau + DMSO, S) Aβ1-42 + Tau + Nilo and T) LacZ + DMSO in the cortex. Histograms represent U) stereological counting of Aβ1-42 positive cells and V) plaque number/mm2 in total brain. Asterisk is significantly different to control (Aβ1-42 + DMSO) or as indicated, bars are mean ± SEM, two-way ANOVA.

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