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Figure 3 | Molecular Neurodegeneration

Figure 3

From: The role of the LRRK2 gene in Parkinsonism

Figure 3

The possible pathogenic mechanism links LRRK2 and Parkinson’s disease α-synuclein, tau, inflammatory response, oxidative stress, mitochondrial dysfunction, synaptic dysfunction and autophagy-lysosomal system all take part in the pathogenic of PD. Open and filled arrows show positive (activating) and negative (suppressing) interactions, respectively.

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