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Table 4 Modelling the relation of anti-AT1R antibodies in HD individuals to disease-related outcomes and smoking as well as infection

From: Increase of angiotensin II type 1 receptor auto-antibodies in Huntington’s disease

  

Standardized Beta

T

p-Value

Model - Step 1

IS

- 0.50

- 4.0

< 0.0001

Model - Step 2

IS

0.50

- 4.3

< 0.0001

 

CAG expanded

0.30

2.5

0.016

Model - Step 3

IS

1.1

- 3.9

< 0.0001

 

CAG expanded

0.30

2.6

0.014

 

Shoulson

0.60

- 2.2

0.03

  1. A linear regression was performed to predict anti-AT1R antibody titers via infection, smoking and HD-relevant variables with additional variables “onset motor” and “onset psychiatric” (n = 48, i.e. only smokers with infection and motor as well as psychiatric onset of disease were included). A stepwise analysis revealed in a first step independence scale (IS), in a second step CAG expanded and in a third step the variable Shoulson scale as predictor. Other variables were not relevant for predicting the presence of anti-AT1R antibody titers in this subgroup.