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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia

Figure 1

Proteolytic processing of BRI 2 . Schematic diagram representing the proteolytic events of BRI2 processing. Proprotein convertases (PC) release a C-terminal 23-residue peptide (Bri2-23). Cleavage by ADAM10 of the BRI2 ectodomain releases the Brichos domain to the extracellular space and leaves an N-terminal fragment (NTF) attached to the membrane. NTF is further processed by signal peptide peptidase-like 2 (SPPL2) generating an intracellular domain (ICD) and an extracellular BRI2 –C-terminal peptide (BRi2-C peptide). Instead of Bri2-23, cleavage of the mutant BRI2 by PC releases ABri in FBD or ADan in FDD, respectively (not depicted). im-BRI2, immature BRI2; m-BRI2, mature BRI2. Glyc, glycosylation; TM, trans-membrane; ICD, intracellular domain.

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Molecular Neurodegeneration

ISSN: 1750-1326