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Figure 7 | Molecular Neurodegeneration

Figure 7

From: Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia

Figure 7

Age and amyloid peptide-dependent toxicity in the CNS. Pan-neuronal transgene expression was induced using the elav-GAL4 driver. A, negative geotaxis assays were performed at the indicated times with flies expressing two copies of the transgenes. The slight decline in climbing performance with age in non-transgenic flies has been reported [reviewed in 36]. ADan expression was associated with reduced climbing at 7 days of age while the toxic effect of ABri and Aβ42 was seen at 15 and 21 days, respectively. Climbing was expressed in cm as the mean ± SEM. Data from 5 technical replicates from each of 3 independent biological experiments per genotype were analyzed. B, phototaxis assays were performed at the indicated times with flies expressing one copy of each transgene. At 25 days p.e, flies expressing ADan had a lower light response in comparison to Bri2-23, Aβ42 or ABri. Results from 2 technical replicates from each of 3 independent biological experiments per genotype are shown. Phototaxis was expressed as the percentage (mean ± SEM) of flies that responded to light. Asterisks indicate statistically significant differences, (*p < 0.05; ** p < 0.01; *** p < 0.001). Geotaxis and Phototaxis data were statistically analyzed by two-way repeated measures ANOVA, followed by Bonferroni’s comparison test for all genotypes and time points which are shown in Additional file 5.

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