Figure 4From: The impact of human and mouse differences in NOS2 gene expression on the brain’s redox and immune environmentComparison of gene expression for selected genes. Genes that showed changes in expression levels between WT and HuNOS2tg/mNos2-/- mice were also examined for expression levels in mNos2-/- mice. Brain lysates were prepared from saline-injected (white bars) and LPS-injected (black bars) mNos2 knockout mice as described and gene expression measured using qRT-PCR. Average fold changes (±sem) for each gene in saline and LPS-treated conditions were determined using the average WT saline-injected value as comparator. Statistical significance across genotypes and treatment was determined using two-way ANOVA (GraphPad Software, San Diego CA). Significance was set at p ≤0.05. *p <0.05; **p <0.01 for comparisons with treatment; #p <0.05, ##p <0.01 for comparisons across strains. n = 5–6 mice per group.Back to article page