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Table 1 LPS-stimulated gene expression differences between HuNOS2 -/- /mNos2 -/- and WT mice brain at 24 hrs post injection

From: The impact of human and mouse differences in NOS2 gene expression on the brain’s redox and immune environment

Gene abbreviation

Gene name

Significantly different

*Prdx3

Periredoxin 3

WT>HN

Prdx4

Periredoxin 4

WT>HN

Prdx5

Periredoxin 5

WT>HN

Gsr

Glutathione reductase

WT>HN

Cyba

NADPH oxidase Cytochrome- b subunit a

HN>WT

Cat

Catalase

WT>HN

Epx

Eosinophil peroxidase

HN>WT

Gpx4

Glutathione peroxidase 4

HN>WT

Nqo1

NAD(P)H dehydrogenase 1-Quinone 1

WT>HN

Gsr

Glutathione reductase

WT>HN

*Lpo

lactoperoxidase

HN>WT

Ireb2

Iron responsive element binding protein 2

WT>HN

RAD51

RAD51 recombinase

HN>WT

*Recql4

REC-q like protein 4 (helicase)

ND

Hbq1

Hemoglobin theta 1

WT>HN

*IL-22

Interleukin 22

HN>WT

Rag2

Recombination activating gene 2

WT>HN

Slc38a1

Solute Carrier 38a1 (glutamine transporter)

WT>HN

  1. *Gene analysis was confirmed by additional RT-PCR (See Figure 4).