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Table 2 Correlation between age, MMSE and biomarker levels in the entire CSF material a

From: SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer’s disease

  SNAP-25, Ac-2-16 SNAP-25, 17-31 SNAP-25, 32-40
Cont (N = 33)    
   Age N.S. N.S. N.S.
   MMSE N.S. N.S. N.S.
   Aβ1-42 rho = 0.560, P = 0.001 rho = 0.468, P = 0.007 N.S.
   T-tau rho = 0.564, P = 0.001 rho = 0.563, P = 0.001 rho = 0.656, P = 0.0001
   P-tau181 rho = 0.735, P < 0.0001 rho = 0.715, P < 0.0001 rho = 0.659, P < 0.0001
   SNAP-25, Ac-2-16 - rho = 0.859, P < 0.0001 rho = 0.718, P < 0.0001
   SNAP-25, 17-31 - - rho = 0.799, P < 0.0001
AD (N = 36)    
   Age N.S. N.S. N.S.
   MMSE rho = -0.509, P = 0.002 N.S. N.S.
   Aβ1-42 N.S. N.S. N.S.
   T-tau rho = 0.557, P = 0.0004 rho = 0.732, P < 0.0001 rho = 0.824, P < 0.0001
   P-tau181 rho = 0.717, P < 0.0001 rho = 0.808, P < 0.0001 rho = 0.835, P < 0.0001
   SNAP-25, Ac-2-16 - rho = 0.836, P < 0.0001 rho = 0.720, P < 0.0001
   SNAP-25, 17-31 - - rho = 0.900, P < 0.0001
  1. Abbreviations: Aβ1-42 (amyloidβ 1-42), AD (Alzheimer’s disease), CSF (cerebrospinal fluid), MMSE (mini-mental state examination), T-tau (total tau), P-tau181 (tau phosphorylated at threonine 181).
  2. aCorrelations presented by the Spearman’s rank correlation coefficient (rho). Non significant (N.S.) (P-value > 0.05) correlations were not reported.