Figure 1
From: Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice
Open-field locomotor performance enhanced in P301S transgenic mice after 12-weeks of forced treadmill exercise. Transgenic exercised mice (Tg-EX) showed locomotor improvements in total activity (A), total distance traveled (B), and ambulatory activity (C) when compared to transgenic sedentary mice (Tg-SED). No significant changes were observed in rearing (D), stereotypic activity (E) and time spent in the center (F). [NTg-SED (n = 10), NTg-EX (n = 8), Tg-SED (n = 6), Tg-EX (n = 8)]. *p < 0.05 = Tg-SED vs Tg-EX. A two-way ANOVA with the Newman-Keuls post-hoc was used to detect statistically significant differences.