Figure 3
From: Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice
Total and phosphorylated tau immunofluorescence is reduced in the spinal cord and brain of P301S transgenic mice after 12-weeks of forced treadmill exercise. A) Total (TAU5) and phosphorylated (AT8, AT100, and AT180) tau were significantly reduced in the spinal cord of the exercised P301S mice. B) No statistically significant changes in total and phosphorylated tau immunofluorescence were observed in in the cortex exercised versus sedentary transgenic mice. C) Significant reductions in TAU5 and AT8 were observed in the hippocampus of exercised P301S mice. D) Exercise significantly affected TAU5 immunofluorescence in the CA1 versus the CA3 of the hippocampus. [n = 6-8 per group]; (*) denotes a significant difference (p < 0.05). A Student’s t-test was used to detect statistically significant differences.