Figure 4
From: Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice
RIPA-soluble and sarkosyl-insoluble tau levels in the spinal cord, cortex, and hippocampus of P301S transgenic mice. RIPA-soluble total (TAU5) and phosphorylated (AT8, AT100, AT180) protein quantification via Western blot analysis of the A) spinal cord, C) cortex, and E) hippocampus revealed no significant reductions in exercised versus sedentary P301S mice. Sarkysol-insoluble total and phosphorylated Western blot analysis of the D) cortex and F) hippocampus did not reveal significant reductions in exercised versus sedentary P301S mice, however the B) spinal cord revealed a significant reduction in AT8-tau. [n = 6-8 per group] (*) denotes a significant difference (p < 0.05). Student’s t-test was used to detect statistically significant differences.