Figure 7
From: Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice
LC3-II and p62/SQSTM1 Western blot analysis. A) There were no significant effects of exercise on LC3-II levels in P301S or non-transgenic mice in the spinal cord, cortex, and hippocampus. [N = 3-4 per group] B) Representative western blots of LC3-II. C) There were no significant effects of exercise on p62/SQSTM1 levels in P301S or non-transgenic mice in the spinal cord, cortex, and hippocampus. Intense 37, 25, and 20 kDa bands were observed in P301S mice, an indication of proteolytic cleavage. [N = 3-4 per group] D) Representative western blots of p62/SQSTM1. E) Representative western blots of sarkosyl-insoluble LC3-II and p62/SQSTM1 in the hippocampus, cortex, and spinal cord.