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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injury

Figure 3

CHIMERA rTBI induces diffuse axonal injury. Axonal degeneration was assessed by silver staining at 2, 7, and 14d post-rTBI. (A) Coronal sections showing white matter areas including the olfactory nerve layer, corpus callosum, and optic tract with regions of prominent silver staining indicated by black rectangles. (B) Representative 40X-magnified images of the same brain regions in sham-operated (upper row) or rTBI-induced (lower three rows) animals at the indicated time points. (C) 100X-magnified images of the same brain regions in rTBI-induced animals. Axonal varicosities are indicated by arrows.

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Molecular Neurodegeneration

ISSN: 1750-1326