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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injury

Figure 5

CHIMERA rTBI induces widespread microglial activation. Microglial activation was assessed using Iba-1 immunohistochemistry at 2, 7, and 14d post-rTBI. (A) Representative images of Iba-1 stained coronal sections of olfactory bulb and brain. Areas with prominent microglial activation are indicated by black rectangles. (B) Representative 40X-magnified images of the same white matter tract regions showing resting microglia in sham brains (upper row) and activated microglia in injured brains (lower three rows) at the indicated time points. (C) Representative 100X-magnified images showing the morphology of Iba-1-stained resting microglia in sham (upper row) and activated microglia in rTBI (lower row) brains.

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Molecular Neurodegeneration

ISSN: 1750-1326