Role of p53-IL-1β interaction on glutamate synaptic transmission. A. The graph shows that application of IL-1β, in mice brain slices, significantly enhanced sEPSC frequency (p < 0.05 respect to pre-drug values), an effect fully prevented by both IL-1ra and the p53 inhibitor PFT (p < 0.05 respect to pre-drug values). The electrophysiological traces on the right are examples of sEPSCs recorded from single striatal neurons, before and during the application of IL-1β, in control conditions and in slices pre-treated with PFT. B. PFT failed to affect TNF-α effects on sEPSC duration (p > 0.05). The electrophysiological traces on the right are examples of sEPSC mean peak, obtained by group analysis and recorded from striatal neurons in the presence of TNF-α and PFT. *means p < 0.05.