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Table 2 p values for p53 gene/IL-1β interaction effects

From: Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53

  TP53 genotype dominant model recessive model
PI 0.002 0.73 0.01
MSSS 0.02 0.30 0.02
MV 0.04 0.16 0.03
RNFL thickness 0.01 0.02 0.005
  1. PI, progression index; MSSS, Multiple Sclerosis Severity Scale; MV, macular volume; RNFL, retinal nerve fiber layer. Although our sample was too small to test other statistical associations, higher values of both PI and MSSS were present in Arg/Arg carriers among patients with undetectable IL-1β (PI: Pro/Pro 0.16 +/- 0.13, Arg/Pro 0.14 +/- 0.09, Arg/Arg 0.21 +/- 0.17; MSSS: Pro/Pro 1.73 +/- 1.62, Arg/Pro 1.73 +/- 1.68, Arg/Arg 2.61 +/- 2.33).
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Molecular Neurodegeneration

ISSN: 1750-1326