Skip to main content

Table 2 p values for p53 gene/IL-1β interaction effects

From: Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53

 

TP53 genotype

dominant model

recessive model

PI

0.002

0.73

0.01

MSSS

0.02

0.30

0.02

MV

0.04

0.16

0.03

RNFL thickness

0.01

0.02

0.005

  1. PI, progression index; MSSS, Multiple Sclerosis Severity Scale; MV, macular volume; RNFL, retinal nerve fiber layer. Although our sample was too small to test other statistical associations, higher values of both PI and MSSS were present in Arg/Arg carriers among patients with undetectable IL-1β (PI: Pro/Pro 0.16 +/- 0.13, Arg/Pro 0.14 +/- 0.09, Arg/Arg 0.21 +/- 0.17; MSSS: Pro/Pro 1.73 +/- 1.62, Arg/Pro 1.73 +/- 1.68, Arg/Arg 2.61 +/- 2.33).
Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326