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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice

Figure 5

Metabolite levels (Means ± SEM) expressed as a percentage of total signal acquired over time from1H MRS scans of (red) HIV-1 infected (n = 8) and (black) uninfected humanized mouse controls (n = 7). (A) Region selected for spectral acquisition from the cerebral cortex. (B) Selected metabolite levels are measured from the cerebral cortex. Time zero, in infected mice is before infection with subsequent spectra acquired every four weeks to 16 weeks in both infected and control mice. (C) Region selected for acquisition of spectrum from cerebellum. (D) The same metabolites as shown in (B). Time courses of all metabolites are shown in Additional files 3 and 4. *p < 0.05 control versus HIV-1 infected mice, +p < 0.05 vs time zero in control mice, (red “+” symbol) p < 0.05 versus preinfection in infected mice.

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