Table 1 Effects of cholesterol increase on expression levels of genes involved in the cholesterol biosynthetic pathway in cultured neurons
Gene acronym | Gene full name | Cholesterol/control expression ratio | P value (t test) |
|---|---|---|---|
Acat2 | Acetyl-Coenzyme A acetyltransferase 2 | 0.32 | 0.00235 |
Cyp51 | Cytochrome P450, family 51 | 0.48 | 0.00698 |
Dhcr24 | 24-dehydrocholesterol reductase | NA | NA |
Dhcr7 | 7-dehydrocholesterol reductase | 0.41 | 0.0278 |
Ebp | Emopamil binding protein (sterol isomerase) | 0.72 | 0.06112 |
Fdft1 | Farnesyl diphosphate farnesyl transferase 1 | 0.38 | 0.03888 |
Fdps | Farnesyl diphosphate synthase | 0.42 | 0.11898 |
Hmgcr | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.57 | 0.28355 |
Hmgcs1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.38 | 0.00355 |
Idi1 | Isopentenyl-diphosphate delta isomerase 1 | 0.38 | 0.03937 |
Lbr | Lamin B receptor | 0.64 | 0.03795 |
Lss | Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.56 | 0.13084 |
Mvd | Mevalonate (diphospho) decarboxylase | 0.28 | 0.01896 |
Mvk | Mevalonate kinase | 0.49 | 0.00199 |
Nsdhl | NAD(P) dependent steroid dehydrogenase-like | 0.49 | 0.05092 |
Pmvk | Phosphomevalonate kinase | 1.16 | 0.74918 |
Sc5d | Sterol-C5-desaturase | 0.41 | 0.00863 |
Sqle | Squalene epoxidase | 0.39 | 0.018 |