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Table 2 Effects of cholesterol increase on expression levels of genes involved in the endo-lysosomal pathway in cultured neurons

From: Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes

Gene acronym

Microarrays

Quantitative PCR

Cholesterol/control expression ratio

P value (t test)

Cholesterol/control expression ratio

P value (t test)

Plcb1

1.45

0.0471

1.33

0.03239

Pik3r1

1.49

0.00279

1.31

0.01416

Osbpl1a

1.64

0.00524

1.52

0.02127

Fyn

1.58

0.02038

1.21

0.03649

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Molecular Neurodegeneration

ISSN: 1750-1326