Figure 7From: Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 miceMechanism of ANDRO action in the synaptic neuroprotection of Aβ oligomers. The presence of Aβ oligomers induces an increase in GSK-3β, which facilitates the process of LTD and which contributes to the internalization of AMPA receptors from the postsynaptic region, reducing the synaptic strength. However, the presence of ANDRO induces GSK-3β inhibition, which, in turn, reduces PSD-95 phosphorylation, preventing the internalization of AMPA receptors and inhibiting the Aβ oligomeric effect on synaptic depression.Back to article page