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Figure 11 | Molecular Neurodegeneration

Figure 11

From: Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model

Figure 11

Older rTg4510 B6 mice have equivalent gross neurodegeneration. Gross brain and hippocampal atrophy was equivalent in rTg4510B6 and rTg4510 mice at 6.5 and 10.5 months of age. (A) All mice on an F1 FVB/B6 background had smaller hemi-brains than all mice on an F1 FVB/129S background (p < 0.05). Independent of strain background, hemi-brain weights for rTg4510 mice were significantly decreased compared to NT mice. (B) Hippocampal atrophy, as assessed by decreased hippocampal area, was significantly increased in age-matched rTg4510 mice compared to NT littermates, with no difference between rTg4510 mice on different strain backgrounds. (C) rTg4510B6 and rTg4510 mice had similar CA1 index values that were significantly less than that of NT mice, indicating increased neuronal loss in the CA1 hippocampal sub-region. (D)  Overall, rTg4510 mice had gross atrophy of the forebrain and ventricle enlargement compared to NT mice that was indistinguishable between age-matched rTg4510 mice on different strain backgrounds. In rTg4510 mice, the hippocampal formation was visibly reduced in size with substantial thinning of the neuronal layers in the CA1 and dentate gyrus sub-regions. (A-C) Each dot represents an individual mouse with the mean indicated by the black line. Data was analyzed via multifactorial (age x genotype x strain) ANOVA. ***p < 0.001 (main effect of genotype indicated). n = 2-7 per cohort. Scale bars represent 200 μm.

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