Skip to main content
Figure 5 | Molecular Neurodegeneration

Figure 5

From: Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model

Figure 5

rTg4510 B6 and rTg4510 mice have equivalent cognitive deficits at 2.5 months of age. Spatial learning and memory was equivalently impaired in rTg4510B6 and rTg4510 mice at 2.5 months of age. (A) rTg4510 mice took significantly more time to find the hidden platform than NT mice (p < 0.001), with no difference between the strain backgrounds. (B) The search paths to reach the hidden platform for both rTg4510B6 and rTg4510 mice were equivalent and significantly longer than the search paths of NT mice (p < 0.001). (C) rTg4510B6 and rTg4510 mice also had similar thigmotaxic swimming that was significantly longer than that of NT mice (p < 0.001). (D) Spatial memory was equally impaired in rTg4510B6 and rTg4510 mice compared to age-matched NT mice as indicated by the decreased percentage of distance traveled in the target quadrant (TQ) during the final probe trial. (A-C) Data expressed as mean ± SEM and analyzed via multifactorial (genotype x strain) RM ANOVA. (D) Each dot represents an individual mouse with the mean indicated by the black line. ****p < 0.0001 [two-way ANOVA (genotype x strain): main effect of genotype indicated]. n = 5 per cohort.

Back to article page