Figure 7
From: Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model
Accumulation and phosphorylation of insoluble tau is not significantly changed in older rTg4510 B6 mice. (A-B) Western blot analyses of the sarkosyl-insoluble fractions of whole brain lysates from rTg4510B6 and rTg4510 mice at 6.5 and 10.5 months of age. (A) Representative western blots of insoluble human and phosphorylated tau with a NT littermate shown as a negative control. (B) Densitometric quantification of E1 (human tau), CP13 (pS202 tau) and PHF1 (pS396/404 tau). Phospho-tau is normalized to the amount of human tau aggregated in that fraction. Each dot represents an individual mouse with the mean indicated by the black line. n = 3-4 per cohort.