Figure 8
From: Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model
Older rTg4510 B6 mice have region-specific increases in CP13 compared to rTg4510 mice. rTg4510B6 mice had increased CP13 (pS202 tau) staining in the cortex and hippocampus, but not the brainstem regions of the brain compared to rTg4510 mice at 10.5 months of age. (A) Representative images of cortical, hippocampal and brainstem regions of 6.5- and 10.5-month-old rTg4510B6 and rTg4510 mice stained with the CP13 antibody. (B) Quantitative analyses of the stained sections showed that the CP13 burden in the cortex of rTg4510B6 mice was significantly greater than the corresponding regions of rTg4510 mice at 10.5 months, but not 6.5 months of age, and increased in the hippocampus of rTg4510B6 at both age points. Each dot represents an individual mouse with the mean indicated by the black line, n = 3-5 per cohort. ***p < 0.001 [two-way ANOVA (strain x age): main effect of strain indicated]. ##p < 0.01 (post hoc Bonferonni’s multiple comparisons test). Scale bar represents 200 μm.