Skip to main content
Figure 5 | Molecular Neurodegeneration

Figure 5

From: Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

Figure 5

Viral mediated expression of apoE4 in apoE4-TR mice leads to increases of mouse endogenous Aβ. Neonatal P2 apoE3-TR or apoE4-TR mice were injected with AAV viruses and brains were harvested as in Figure 2. (A and B) Levels of mouse endogenous Aβ in the cortices of apoE3-TR mice (A) or apoE4-TR mice (B) transduced with AAV viruses encoding GFP or apoE isoforms were quantified by mouse Aβ-specific ELISA. Data are expressed as mean ± SEM (n = 7-8/group). N.S., Not significant; *,p < 0.05; **,p < 0.01.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326