Figure 1

Age-dependent decline in Y-maze of performance in E4FAD mice compared to E3FAD and E2FAD mice. Results at 2-, 4-, and 6-months of age for E2FAD, E3FAD, E4FAD, and 5×FAD/APOE-KO mice: Y-maze results for (A) the total number of arm entries, (B) percent alternation, (C) novel arm recognition, and (D) time spent in novel arms. N ≥ 6 per group, expressed as means ± S.E.M. Significant differences at p < 0.05 via two-way ANOVA, Bonferroni post-hoc test identified by: † between E2FAD and E3FAD, § between E2FAD and E4FAD, ^¶between E3FAD and E4FAD. Color matched ^‡(green = E2FAD, blue = E3FAD, red = E4FAD, grey = 5×FAD/APOE-KO) between EFAD strain and 5×FAD/APOE-KO. Along the x-axis, color matched *indicates significant differences between time points within a mouse strain. There is no significant change with age unless marked.