Figure 2

Age-dependent decline in Morris water maze training and performance is exacerbated in E4FAD and 5xFAD/ APOE -KO mice compared to E3FAD and E2FAD mice. Results at 2-, 4-, and 6-months of age for E2FAD, E3FAD, E4FAD, and 5xFAD/APOE-KO mice: (A) Representative swimming tracks in Morris water maze for days 1-5 of training (APOE-KO = 5xFAD/APOE-KO). (B) Training trials: Escape latency for hidden platform. (C) Probe trials: time spent in target quadrant and number of platform crossings. N ≥ 6 per group, expressed as means ± S.E.M. Significant differences at p < 0.05 via two-way ANOVA, Bonferroni post-hoc test identified by: ^†between E2FAD and E3FAD, § between E2FAD and E4FAD, ^¶between E3FAD and E4FAD. Color matched ^‡(green = E2FAD, blue = E3FAD, red = E4FAD, grey = 5xFAD/APOE-KO) between EFAD strain and 5xFAD/APOE-KO. Along the x-axis, color matched *indicates significant differences between time points within a mouse strain. There is no significant change with age unless marked.