Figure 1From: Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model CD2AP shRNAs decreased extracellular Aβ levels in cell culture. N2a-695 cells were transfected with CD2AP shRNAs or control shRNA. (A- C) Aβ40, Aβ42 and Aβ42/Aβ40 ratio in the cell culture medium. (D- F) Aβ40, Aβ42 and Aβ42/Aβ40 ratio in the cell lysates (n = 5/group; *, p < 0.05, **, p < 0.01, ***, p < 0.001, one-way ANOVA followed by Tukey test).Back to article page