Skip to main content
Figure 6 | Molecular Neurodegeneration

Figure 6

From: Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model

Figure 6

Effects of CD2AP haploinsufficiency on Aβ plaque deposition in 7-month old PS1APP mice. PS1APP/CD2AP+/+ (n = 19 total, 10 females and 9 males) and PS1APP/CD2AP+/− (n = 18 total, 9 females and 9 males) mice were sacrificed. (A) Representative images for Aβ staining in PS1APP/CD2AP+/+ and PS1APP/CD2AP+/− cortex (Scale bar =400 μm). (B) Quantification of Aβ plaque load in PS1APP/CD2AP+/+ and PS1APP/CD2AP+/− cortex. (C) Representative images of Thioflavin S staining in PS1APP/CD2AP+/+ and PS1APP/CD2AP+/− cortex (Scale bar =400 μm). (D) Quantification of fibrillar plaque load in PS1APP/CD2AP+/+ and PS1APP/CD2AP+/− cortex.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326