Figure 7
From: Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease
Schematic diagram of the role of Aβ in circadian rhythm disruption. This diagram describes the signaling cascade between AD and circadian rhythm, focusing on the role of Aβ. Based on our experimental data, Aβ can regulate BMAL1 and CBP degradation under conditions of Aβ-induced damage. BMAL1 degradation is mediated by Aβ-induced BMAL1 sumoylation. CBP degradation is mediated by Aβ-induced N-Cadherin cleavage. Thus, Aβ-induced BMAL1 and CBP expression results in disrupted PER2 oscillation and circadian rhythm disruption.