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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy

Figure 5

Immunization with AFF-1 modulates cytokine levels in MBP-α-syn tg mice. Cytokine levels in the cytosolic fraction of non-tg or MBP-α-syn tg mice treated with vehicle or AFF 1 were analyzed using a proteomic array. Results are expressed as optical density relative to the non-tg vehicle condition. (A) IL-1Ra (B) IL-3 (C) IFNγ (D) IL-1α (E) GM-CSF. Results are expressed as average ± SEM. (*) p < 0.05, (**) p < 0.01 when comparing vehicle-treated non-tg animals with vehicle-treated tg animals by two-way ANOVA with post hoc Tukey. (#) p < 0.05, (##) p < 0.01 when comparing vehicle-treated tg animals with AFF 1-treated tg animals by two-way ANOVA with post hoc Tukey. n = 4 animals per group.

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Molecular Neurodegeneration

ISSN: 1750-1326