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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Lazarillo-related Lipocalins confer long-term protection against type I Spinocerebellar Ataxia degeneration contributing to optimize selective autophagy

Figure 3

NLaz is over-expressed in response to hATXN1 82Q -dependent photoreceptor degeneration, and its over-expression with the GAL4/UAS system rescues the pathogenic phenotype. A, RT-qPCR levels of NLaz mRNA in 5–6 day old fly heads. Statistical differences were assayed by Mann–Whitney U-test. *P < 0.05. B, Representative fly eyes and hematoxilin/eosin histochemistry of paraffin sections showing the degenerated phenotype (gmr > hATXN182Q) and the NLaz rescue (gmr > hATXN182Q + NLazC5). Arrows mark the retina thickness in the histological sections. C, Photoreceptor degeneration rescue observed when co-expressing hATXN182Q with the Lipocalins NLaz and GLaz. D, Quantification of photoreceptor degeneration rescue for NLaz and the co-expression of NLaz and GLaz. Asterisk represents statistically significant differences (Student’s t-test, *P < 0.05) with respect to the degenerated gmr > hATXN182Q genotype.

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