Decrease of ubiquitinated proteins build-up attained by GLaz over-expression. A, Ubiquitin HRP-immunohistochemistry on paraffin sections of control, degenerated and GLaz-rescued retinas shows the decrease in ubiquitin labeling when over-expressing GLaz. B, Ubiquitinated protein load measured by ubiquitin immunoblot signal in different lines expressing the pathogenic hATXN182Q alone or in combination with GLaz-expressing transgenes. Statistical differences were assayed by Student’s t-test. *P < 0.05.