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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Lazarillo-related Lipocalins confer long-term protection against type I Spinocerebellar Ataxia degeneration contributing to optimize selective autophagy

Figure 5

Decrease of ubiquitinated proteins build-up attained by GLaz over-expression. A, Ubiquitin HRP-immunohistochemistry on paraffin sections of control, degenerated and GLaz-rescued retinas shows the decrease in ubiquitin labeling when over-expressing GLaz. B, Ubiquitinated protein load measured by ubiquitin immunoblot signal in different lines expressing the pathogenic hATXN182Q alone or in combination with GLaz-expressing transgenes. Statistical differences were assayed by Studentā€™s t-test. *Pā€‰<ā€‰0.05.

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