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Figure 8 | Molecular Neurodegeneration

Figure 8

From: Lazarillo-related Lipocalins confer long-term protection against type I Spinocerebellar Ataxia degeneration contributing to optimize selective autophagy

Figure 8

Effects on Atg8a and p62 expression of GLaz loss- and gain-of-function in control conditions. A-B, Immunofluorescence of control (either WTG10 or gmrā€‰>ā€‰+), GLaz loss-of-function (GLazĪ”2/Ī”2) and GLaz gain-of-function (gmrā€‰>ā€‰GLaz2) retinas showing p62 protein expression. C, mRNA levels of p62, measured by RT-qPCR in control and GLaz loss- and gain-of-function fly heads. D, mRNA levels of Atg8a, measured by RT-qPCR in control, GLaz loss- and gain-of-function fly heads. Statistical differences were assayed by Studentā€™s t-test (immunofluorescence) and Mannā€“Whitney U-test (RT-qPCR). *Pā€‰<ā€‰0.05.

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