Figure 9

Epistasis analysis of GLaz with down-regulators of autophagy. A, Quantitative estimate of degeneration by computing a regularity index based on the variance (σ) of the local intensity maxima distances. A percent recovery of the degeneration is indicated for each genotype. 20–35 eyes/genotype were used to compute regularity indexes. Average ± S.E.M. are represented. Asterisk represents statistically significant differences (Student’s t-test, *P < 0.05) with respect to the degenerated gmr > hATXN1^82Q genotype. B-E, Adult (3d old) Drosophila eye morphology of gmr > hATXN1^82Q + autophagy down-regulators, compared to gmr > hATXN1^82Q + GLaz2 + autophagy down-regulators. Representative examples of light microscopy and surface filter-processed image of the central retinal region are shown.