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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

Figure 5

Acetylated tau in rTg4510 brain. A. Western blot of acetylated tau probed by ac-280, a polyclonal antibody specific for tau acetylated at Lys280. B. Age-dependent change of acetylated tau in the soluble and insoluble fractions of rTg4510 mouse brain. Acetylated tau was measured using 1 μg of protein from the soluble or insoluble fractions of rTg4510 mouse brain with biotin HT7 for capture and a pan acetyl-lysine antibody for detection. The error bars represent the standard error for each group. The change of ac-tau reached statistical significance at 14-weeks of age as compared to 8-weeks (p < 0.05, one-way ANOVA). C. Correlation of the levels of acetylated tau and PHF6 tau in the insoluble fraction of rTg4510 mouse brain.

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