Figure 1

VAMP1 variants are associated with altered VAMP1 transcript levels in cerebellum. Box (25^th-75^th percentiles) and whisker (range of the data) plots are shown for VAMP1 mRNA expression (-Δ_CT) in 365 cerebella samples (pooled Alzheimer’s and controls) grouped by VAMP1 genotype (0, 1, 2 = number of copies of the minor allele). For ease of interpretation, the negative of the Δ_CT (-Δ_CT) are plotted here such that a negative value represents a decrease in expression and a positive value an increase in expression. The β co-efficient (-β for ease of interpretation) and p-values (p) for the logistic regression of Δ_CT versus VAMP1 genotype (adjusted for age, sex and APOE ε4 allele) are given. Analyses were performed following additive, dominant and recessive models; the best model (lowest p-value) for each polymorphism is shown. For results in AD and Control subsets and for all models tested, see Additional file 1: Table S3. The location of each polymorphism within VAMP1 is indicated. The scaled schematic represents the full VAMP1 sequence (line) in the 5′ to 3′ direction including exons (boxes) and 3′untranlsated region (arrowed box).