A high dose of rAAV2/7-WT α-SYN induces similar dopaminergic degeneration in parkin−/− and parkin+/+ mice. Stereological quantification of the number of TH-positive neurons in the SN of parkin+/+ and parkin−/− mice at (A) 1 week and 4 weeks after injection with a high titer of rAAV2/7-WT α-SYN and at (B) 4 weeks after injection with rAAV2/7-eGFP. (C) quantification of TH staining in striatum (injected over non-injected side) of parkin+/+ and parkin−/− mice 4 weeks after injection. Asterisks depict significant decrease respective to 1 week, unless specified otherwise. (Mean ± SEM, two-way ANOVA followed by Bonferroni post-hoc test, ** p < 0.01 ***p < 0.001, 1 week rAAV2/7-WT α-SYN: n = 4; 4 weeks rAAV2/7-WT α-SYN: n = 15-16; 4 weeks rAAV2/7-eGFP: n = 5-6).