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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration

Figure 5

A low dose of rAAV2/7-WT α-SYN induces similar dopaminergic degeneration in parkin−/− and parkin+/+ mice. (A) Representative images of immunohistochemical staining for TH in the SN at 1 week, 4 weeks, 8 weeks and 16 weeks after injection with a low titer of rAAV2/7-WT α-SYN. Scale bar = 400 μm. (B) Stereological quantification of the number of TH-positive neurons in the SN of parkin+/+ and parkin−/− mice at 1 week, 4 weeks, 8 weeks and 16 weeks after injection with a low titer of rAAV2/7-WT α-SYN. (Mean ± SEM, two-way ANOVA followed by Bonferroni post-hoc test, *p < 0.05, **p < 0.01, n = 2-3 at 1 week, n = 10-13 at 4 weeks, n = 5-6 at 8 weeks, n = 6 at 16 weeks).

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Molecular Neurodegeneration

ISSN: 1750-1326