Figure 5
From: Making (anti-) sense out of huntingtin levels in Huntington disease
Wild-type and mutant htt protein levels in HD fibroblasts and brain tissue. (A) Western blot analysis of total protein lysates from human fibroblasts from three HD patients (GM02173, GM04022, GM04855). The lower band represents wild-type htt, the upper band mutant htt. PolyQ repeat lengths are indicated below each lane. (B) Western blot analysis of cortical brain homogenates from six HD subjects. (C) Whisker box plots comparing wild-type and mutant htt levels normalized against total htt in HD fibroblasts (n = 3) and (D) post-mortem brain tissue (n = 6). Pair wise differences were evaluated using linear mixed model.