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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Identification of telomere dysfunction in Friedreich ataxia

Fig. 1

Telomere length analysis of FRDA cells. a Mean telomere length determinations of mouse FRDA fibroblast cells by Q-FISH, showing significantly increased telomeric repeat fluorescence in YG8R and YG22R FRDA mice compared to Y47R and B6 controls. The LY-R long telomere control also showed 6 times greater telomere fluorescence than the LY-S short telomere control. n = 100. b Mean telomere length of human FRDA fibroblasts by Q-FISH showed significantly higher telomere fluorescence in all the FRDA fibroblast cells compared to the controls. n = 150. c Mean telomere length of the FRDA patient fibroblasts (n = 3) measured by qPCR was significantly greater than the normal fibroblast (n = 3) and epithelial controls (n = 3). d Mean telomere length of the FRDA leukocytes (n = 18) measured by qPCR was significantly lower compared to the controls (n = 12). All data are shown as mean ± SEM (* P < 0.05 and *** P < 0.001, evaluated by Student’s t test). All qPCR runs were performed in triplicate and each experiment was repeated independently, at least twice

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