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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment

Fig. 2

Multiple cerebral occluded lesions in eNOS+/- mice. a, b Representative FITC-dextran angiographic micrographs in young (a) and aged eNOS mice (b). Arrows indicate infarctions in hippocampus; red double arrows, bilateral lesions; asterisks, parietal association cortex; daggers, retrosplenial granular cortex; arrowheads, temporal association/temporoparietal cortexes. Scale bars: 100 μm (a) and 500 μm (b). c Quantification of the number of cerebral nonperfusion lesions/infarctions per mouse. **P < 0.0005. n = 4–6 mice each genotype. Bars represent mean ± s.e.m. d Representative FITC-dextran angiographic micrographs with DAPI counterstaining. Scale bars: 100 μm. White arrow indicates a nonperfusion lesion. e Representative angiograph shows multiple cerebral occluded lesions in thalamus (double arrows). Scale bar: 1 mm

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Molecular Neurodegeneration

ISSN: 1750-1326